Remdesivir Mixed Results, Studying Asymptomatics : COVID 19 Update

Mixed Results for Remdesivir in Moderate Disease

A 5-day course of remdesivir (Veklury) for hospitalized patients with moderate COVID-19 was associated with a statistically significant improvement compared with standard care in a company-sponsored randomized trial. However, experts said the clinical benefit of the drug in these patients is ambiguous given the small difference between trial groups.

In addition, patients randomly assigned to receive a longer, 10-day remdesivir course did not improve significantly, compared with those who received standard care, when they were assessed 11 days after treatment started.

This trial and two previously reported randomized trials all showed varied results with remdesivir, "raising the question of whether the discrepancies are artifacts of study design choices, including patient populations, or whether the drug is less efficacious than hoped," wrote two experts in an accompanying editorial.

Understanding Asymptomatic Infections

According to various estimates, between one fifth to nearly one half of people infected with SARS-CoV-2, and possibly more, never develop symptoms. Scientists don't know why.

The prevailing theory is that the immune systems of asymptomatic people fight off the virus so efficiently that they never get sick. But some scientists are also looking into a phenomenon called disease tolerance, in which an organism may accommodate an infection so seamlessly that no symptoms emerge, Undark reports.

More Clues on How COVID-19 Can Turn Immune System Against Us 

A history of age-related macular degeneration or thrombocytopenia, thrombosis, or hemorrhage are associated with greater risk for COVID-19 morbidity and mortality, new evidence suggests.

The findings emerge from research aimed at uncovering specific ways immune dysregulation contributes to more severe COVID-19. This deeper dive into mechanisms lurking behind poorer clinical outcomes implicates differences in complement and coagulation components of the immune system — both of which are involved in inflammation.

Famotidine Associated With Benefit for Hospitalized Patients 

Administering famotidine to hospitalized COVID-19 patients was associated with a reduction in death and a composite endpoint of either death or intubation, according to an observational study published in the American Journal of Gastroenterology. Of the 878 patients included in the study, 83 (9.5%) received famotidine, and those patients were slightly younger than the patients who did not receive the drug.

Panorama Hispano is the regional news and information newspaper for Hispanic and other diverse communities.

US Hispanics are now the largest ethnic minority in the United States numbering 54.2 million as of July 2014. Serving: Buffalo, Rochester, Fredonia, Niagara Falls, NY and Erie, PA. Outside our Market area: Visit our affiliate at:

Contact us:

Featured News

Dec 1, 2020
Pucho Olivencia Center Starts Pre- Registration for Three Kings Day Gift Giveaway

By: Edwin Martinez Buffalo, NY - The Pucho Olivencia Center has started its annual TheKing Day Celebration which will be held on January 9th. Pre - Registration Starts Monday, November 23rd until Thursday December 17th. Locations for Registration: The Belle Center 104 Maryland St, Buffalo, NY 14201 - Monday to Thursday 4 to 6pm Pucho Olivencia […]

Read More
Nov 30, 2020
This holiday season, everyone is shopping from home

NEW YORK (AP) — The viral pandemic is accelerating a transformation of America’s holiday shopping season. Few people showed up at the mall this weekend, with millions of pandemic-wary shoppers staying home to shop online. The result? Overall holiday sales are projected to rise a slight 0.9% in November and December — and even that […]

Read More
Nov 30, 2020
Buffalo Bills have had their share of hair-raising 2nd-half moments

ORCHARD PARK, N.Y. (AP) — Difficult as it was watching the Buffalo Bills’ maddening inability to close out a win over the Chargers until the final minutes, coach Sean McDermott was at least able to laugh about it afterward. “If I’m laying on the ground one of these days, you’ll know why. You’ll know why,” […]

Read More

popular categories

Featured (1,526)
Mundo Latino (1,018)
Negocios / Tecnología (229)
Salud (183)
COVID 19 Updates (171)
Entretenimiento (147)
Vida y Estilo (224)
Deportes (124)
Locales / Regional (116)
Buffalo (1,161)
Dunkirk (899)
Rochester (869)
NY and Erie (809)
PA (680)
Opinión (86)
Copyright © 2020 Panorama Hispano News. All Rights Reserved.
linkedin facebook pinterest youtube rss twitter instagram facebook-blank rss-blank linkedin-blank pinterest youtube twitter instagram